Reproducibility discrepancies following reanalysis of raw data for a previously published study on diisononyl phthalate (DINP) in rats
A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats" reported statistically significant changes in sperm parameters, testicular histopathology, anogenital distance and retained nipples in developing males. Using the statistical methods as reported by Boberg et al. (2011), we reanalyzed the publically available raw data ([dataset] US EPA (United States Environmental Protection Agency), 2016). The output of our reanalysis and the discordances with the data as published in Boberg et al. (2011) are highlighted herein. Further discussion of the basis for the replication discordances and the insufficiency of the Boberg et al. (2011) response to address them can be found in a companion letter of correspondence (doi: 10.1016/j.reprotox.2017.03.013.; (Morfeld et al., 2011)).
AUTHORS
Chen M, Alyea R, Morfeld P, Otter R, Kemmerling J, Palermo C.
